All products are for laboratory research purposes only. Not for human consumption.
Mitochondria-targeted synthetic tetrapeptide
SS-31
SS-31 is a synthetic tetrapeptide designed to concentrate in the inner mitochondrial membrane, where it associates with cardiolipin. Its alternating aromatic-cationic structure is what drives that targeting. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only.
$106.64 (£84.25) per box of 10 vials · 10 mg, 50 mg
Overview
What is SS-31?
SS-31 is a synthetic tetrapeptide designed to concentrate in the inner mitochondrial membrane, where it associates with cardiolipin. Its alternating aromatic-cationic structure is what drives that targeting. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only.
SS-31 at a glance
| Compound | SS-31 |
|---|---|
| Also known as | Elamipretide, MTP-131, SS31, Bendavia |
| Classification | Mitochondria-targeted synthetic tetrapeptide |
| CAS number | 736992-21-5 |
| Molecular formula | C32H49N9O5 |
| Molecular weight | 639.79 g/mol |
| Sequence | D-Arg-Dmt-Lys-Phe-NH2 |
| Purity | 99%+ by HPLC |
| Physical form | Lyophilised powder |
| Available strengths | 10 mg, 50 mg |
| Box quantity | 10 vials |
| Price from | $10.66 per vial ($106.64 per box) |
| Research status | Investigational, known clinically as elamipretide. Has been through multiple registered clinical trials for mitochondrial disease. Not approved. |
| Documentation | Batch-specific COA (Janoshik or Freedom Diagnostic) |
Nominal specifications. The authoritative figures for any given box are those printed on its batch COA.
Pricing
How much does SS-31 cost?
SS-31 starts at $10.66 per vial (£8.42), sold in boxes of 10 at $106.64. One box is the smallest order and there is no trade account or minimum spend. Larger volumes are negotiable.
| Strength | Per vial | Box of 10 |
|---|---|---|
| 10 mg | $10.66 £8.42 | $106.64 £84.25 |
| 50 mg | $25.43 £20.09 | $254.28 £200.88 |
Handling
How should SS-31 be stored and reconstituted?
Full explanation of why each of these matters: peptide handling and storage reference.
Research Context
What is SS-31 researched for?
Below is a plain-English summary of what published research has investigated, and what it has found. These are descriptions of research activity and published results. They are not claims about what SS-31 does, and nothing here is a statement that it is safe or effective for any purpose.
Cardiolipin binding
SS-31 concentrates in the inner mitochondrial membrane and binds cardiolipin, a lipid found almost nowhere else. Cardiolipin organises the proteins of the respiratory chain, and when it is damaged, energy production drops. 1
Mitochondrial function research
Studies examine whether stabilising cardiolipin restores respiratory efficiency and reduces reactive oxygen species in cells with impaired mitochondria, using oxygen consumption and ROS assays.
Clinical trial history
Elamipretide has been tested in primary mitochondrial myopathy and several other conditions with mixed results. It has one of the more substantial registered trial records of any compound in this catalog. 2
References
- 1The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action. J Biol Chem (2020). PMID 32273339
- 2Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential. Int J Mol Sci (2025). PMC11816484
Links open the record on PubMed or PubMed Central. These are citations to published research, not claims about this product.
Applications
Where SS-31 is used in the laboratory
- Mitochondrial membrane and cardiolipin interaction studies
- Reactive oxygen species and oxidative stress research in cell culture
- Mitochondrial bioenergetics and respiration assays
- Comparative studies alongside other mitochondria-targeted compounds
Verification
Does SS-31 come with a COA?
Yes — every box. Each batch of SS-31 is analysed by Janoshik Analytical or Freedom Diagnostic. The certificate confirms identity by mass spectrometry and purity by HPLC, and is tied to the batch number printed on the vial label. You can ask to see it before you order.
Example COA. You receive the certificate matching your own batch.
Questions
SS-31 questions, answered
Why does SS-31 concentrate in mitochondria?
Its alternating aromatic-cationic residue pattern gives the molecule a net positive charge alongside lipophilic character. That combination drives accumulation in the inner mitochondrial membrane, where it associates with cardiolipin, independently of the membrane potential that most mitochondrial probes rely on.
How much does SS-31 cost?
SS-31 starts at $10.66 per vial, sold in boxes of 10 vials at $106.64 per box (about £84.25). 2 strengths available: 10 mg, 50 mg. There is no minimum order.
What purity is your SS-31?
All batches test at 99%+ purity. Every box ships with a batch-specific Certificate of Analysis from Janoshik Analytical or Freedom Diagnostic, confirming identity by mass spectrometry and purity by HPLC.
Is there a minimum order for SS-31?
No. You can order a single box of 10 vials. There is no trade account, bulk commitment or minimum spend.
How is SS-31 shipped?
Tracked and in discreet, plain packaging, dispatched within 1–3 working days. Delivery estimates are UK 5–7 working days, EU 8–10, USA 5–8 and rest of world 10–12. Full detail is on the shipping page.
Catalog
