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Mitochondrial-derived peptide (MDP), 16 residues
MOTS-c
MOTS-c is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene rather than the nuclear genome. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only.
$92.71 (£73.24) per box of 10 vials · 10 mg, 40 mg
Overview
What is MOTS-c?
MOTS-c is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene rather than the nuclear genome. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only.
MOTS-c at a glance
| Compound | MOTS-c |
|---|---|
| Also known as | MOTS-c peptide, Mitochondrial ORF of the 12S rRNA type-c, MOTSc |
| Classification | Mitochondrial-derived peptide (MDP), 16 residues |
| CAS number | 1627580-64-6 |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | ~2174.6 g/mol |
| Sequence | MRWQEMGYIFYPRKLR |
| Purity | 99%+ by HPLC |
| Physical form | Lyophilised powder |
| Available strengths | 10 mg, 40 mg |
| Box quantity | 10 vials |
| Price from | $9.27 per vial ($92.71 per box) |
| Research status | Preclinical. Studied in cell culture and animal models. No approved human use and no completed large clinical trials. |
| Documentation | Batch-specific COA (Janoshik or Freedom Diagnostic) |
Nominal specifications. The authoritative figures for any given box are those printed on its batch COA.
Pricing
How much does MOTS-c cost?
MOTS-c starts at $9.27 per vial (£7.32), sold in boxes of 10 at $92.71. One box is the smallest order and there is no trade account or minimum spend. Larger volumes are negotiable.
| Strength | Per vial | Box of 10 |
|---|---|---|
| 10 mg | $9.27 £7.32 | $92.71 £73.24 |
| 40 mg | $17.00 £13.43 | $170.00 £134.30 |
Handling
How should MOTS-c be stored and reconstituted?
Full explanation of why each of these matters: peptide handling and storage reference.
Research Context
What is MOTS-c researched for?
Below is a plain-English summary of what published research has investigated, and what it has found. These are descriptions of research activity and published results. They are not claims about what MOTS-c does, and nothing here is a statement that it is safe or effective for any purpose.
AMPK energy signalling
MOTS-c switches on AMP-activated protein kinase, the enzyme cells use to detect that energy is running low. In muscle cell studies this shifts cells toward burning glucose and fat rather than storing them. 1
Exercise and metabolic adaptation
Rodent studies report improved running capacity and insulin sensitivity, and human studies have found blood levels of MOTS-c rise after exercise. The rodent findings have not been reproduced in controlled human trials. 2
Mitochondrial-to-nuclear signalling
MOTS-c is unusual: it is encoded inside mitochondrial DNA but travels to the nucleus and influences nuclear genes. That makes it a working model for how mitochondria communicate with the rest of the cell. 1
References
- 1The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab (2015). PMID 25738459
- 2MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med (2016). PMID 27216708
Links open the record on PubMed or PubMed Central. These are citations to published research, not claims about this product.
Applications
Where MOTS-c is used in the laboratory
- Mitochondrial-derived peptide biology and retrograde mitochondrial-to-nuclear signalling
- AMP-activated protein kinase (AMPK) pathway studies
- Cellular metabolic stress response research
- Comparative studies alongside other mitochondrial-derived peptides such as humanin
Verification
Does MOTS-c come with a COA?
Yes — every box. Each batch of MOTS-c is analysed by Janoshik Analytical or Freedom Diagnostic. The certificate confirms identity by mass spectrometry and purity by HPLC, and is tied to the batch number printed on the vial label. You can ask to see it before you order.
Example COA. You receive the certificate matching your own batch.
Questions
MOTS-c questions, answered
What is a mitochondrial-derived peptide?
Mitochondrial-derived peptides are short peptides encoded by small open reading frames within mitochondrial DNA, rather than by the nuclear genome. MOTS-c is encoded within the 12S rRNA gene and is one of the most studied examples.
How much does MOTS-c cost?
MOTS-c starts at $9.27 per vial, sold in boxes of 10 vials at $92.71 per box (about £73.24). 2 strengths available: 10 mg, 40 mg. There is no minimum order.
What purity is your MOTS-c?
All batches test at 99%+ purity. Every box ships with a batch-specific Certificate of Analysis from Janoshik Analytical or Freedom Diagnostic, confirming identity by mass spectrometry and purity by HPLC.
Is there a minimum order for MOTS-c?
No. You can order a single box of 10 vials. There is no trade account, bulk commitment or minimum spend.
How is MOTS-c shipped?
Tracked and in discreet, plain packaging, dispatched within 1–3 working days. Delivery estimates are UK 5–7 working days, EU 8–10, USA 5–8 and rest of world 10–12. Full detail is on the shipping page.
