MOTS-c Peptide Vials
Mitochondrial-derived peptide (MDP), 16 residues · 10mg–40mg · boxes of 10 vials
Free delivery worldwide on orders over $1,000 (about £749)
Strength 3 options · price per box
Latest third-party test: 99.87%Purity (HPLC) · 10 mg · tested 3 Aug 2026
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- No minimumBoxes of 10 vials
- Tracked shippingDispatched in 1–2 working days
- Batch COAFree on request
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Often ordered together
One box of each. Change strengths or quantities in the cart.
About MOTS-c
What is MOTS-c?
Overview
What is MOTS-c?
MOTS-c is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene rather than the nuclear genome. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only.
MOTS-c at a glance
| Compound | MOTS-c |
|---|---|
| Also known as | MOTS-c peptide, Mitochondrial ORF of the 12S rRNA type-c, MOTSc |
| Classification | Mitochondrial-derived peptide (MDP), 16 residues |
| CAS number | 1627580-64-6 |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | ~2174.6 g/mol |
| Sequence | MRWQEMGYIFYPRKLR |
| PubChem CID | 146675088 |
| Purity | 99%+ by HPLC |
| Physical form | Lyophilised powder |
| Available strengths | 10 mg, 20 mg, 40 mg |
| Box quantity | 10 vials |
| Price from | $8.77 per vial ($87.71 per box) |
| Research status | Preclinical. Studied in cell culture and animal models. No approved human use and no completed large clinical trials. |
| Documentation | Batch-specific third-party COA |
These are catalogue target specifications, not batch results. The 99%+ purity figure is the specification we buy to. The authoritative figures for any particular box are the ones printed on that box’s Certificate of Analysis, which is lot-specific. What research grade actually means explains the difference. Terms such as HPLC purity and net peptide content are explained in the peptide glossary.
We make no “third-party verified” claim for a batch unless the matching report is supplied with it. Ask for the current COA for the lot in stock before you order — we will send it.
Prices for every strength
Pricing
MOTS-c price per vial: 10mg, 20mg and 40mg
MOTS-c starts at $8.77 per vial (£6.57), sold in boxes of 10 at $87.71. One box is the smallest order and there is no trade account or minimum spend. Larger volumes are negotiable.
| Strength | Per vial | Box of 10 |
|---|---|---|
| 10 mg | $8.77 £6.57 | $87.71 £65.71 |
| 20 mg | $13.13 £9.84 | $131.29 £98.36 |
| 40 mg | $16.50 £12.36 | $165.00 £123.62 |
Storage & reconstitution
Handling
How should MOTS-c be stored and reconstituted?
Sealed vials tolerate ambient temperature in transit and keep at −20 °C beyond that. Reconstitute slowly down the vial wall, swirl rather than shake, then refrigerate at 2–8 °C and aliquot before freezing.
Why each of those matters, and what a freeze–thaw cycle actually costs: peptide handling and storage reference. How long a mixed vial keeps: reconstituted peptide shelf life.
What it is researched for
Research Context
What is MOTS-c researched for?
Below is a plain-English summary of what published research has investigated, and what it has found. These are descriptions of research activity and published results. They are not claims about what MOTS-c does, and nothing here is a statement that it is safe or effective for any purpose.
AMPK energy signalling
MOTS-c switches on AMP-activated protein kinase, the enzyme cells use to detect that energy is running low. In muscle cell studies this shifts cells toward burning glucose and fat rather than storing them. 1
Exercise and metabolic adaptation
Rodent work reports improved insulin sensitivity and protection against diet-induced obesity, with skeletal muscle as the apparent target organ. 1 Review literature places MOTS-c in the context of obesity, diabetes, exercise and longevity, 2 but that describes where the field is looking rather than what has been established, and the rodent findings have not been reproduced in controlled human trials.
Mitochondrial-to-nuclear signalling
MOTS-c is unusual: it is encoded by a short open reading frame inside mitochondrial DNA and acts well beyond the organelle, which is the basis for treating mitochondria as a signalling unit rather than only a power source. 1 Translocation to the nucleus has been reported separately and is the more striking version of that claim, but it is not what the founding paper established.
References
- 1The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab (2015). PMID 25738459
- 2MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med (2016). PMID 27216708
Links open the record on PubMed or PubMed Central. These are citations to published research, not claims about this product.
Laboratory uses
Applications
Where MOTS-c is used in the laboratory
- Mitochondrial-derived peptide biology and retrograde mitochondrial-to-nuclear signalling
- AMP-activated protein kinase (AMPK) pathway studies
- Cellular metabolic stress response research
- Comparative studies alongside other mitochondrial-derived peptides such as humanin
Batch COA
Verification
Does MOTS-c come with a COA?
Yes — every box. Each batch of MOTS-c is analysed by an independent third-party laboratory, and the certificate is tied to the batch number on the vial label.
Example COA. You receive the certificate matching your own batch.
Questions & answers
Questions
MOTS-c questions, answered
What is a mitochondrial-derived peptide?
Mitochondrial-derived peptides are short peptides encoded by small open reading frames within mitochondrial DNA, rather than by the nuclear genome. MOTS-c is encoded within the 12S rRNA gene and is one of the most studied examples.
How much does MOTS-c cost?
MOTS-c starts at $8.77 per vial, sold in boxes of 10 vials at $87.71 per box (about £65.71). 3 strengths available: 10 mg, 20 mg, 40 mg. There is no minimum order.
Can I buy MOTS-c 10mg vials in the UK?
Yes. MOTS-c 10mg comes in boxes of 10 vials at $87.71 per box ($8.77 per vial, about £65.71 per box), sent tracked to UK addresses. There is no minimum order.
How is MOTS-c shipped to the UK and USA?
Tracked to the UK, USA, EU and worldwide, in plain packaging, dispatched within 1–2 working days. Country-by-country estimates are on the shipping page.
