IGF-1 LR3 Peptide Vials
Recombinant 83-residue analogue of insulin-like growth factor 1 · 0.1mg–1mg · boxes of 10 vials
Free delivery worldwide on orders over $1,000 (about £749)
Strength 2 options · price per box
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- No minimumBoxes of 10 vials
- Tracked shippingDispatched in 1–2 working days
- Batch COAFree on request
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Often ordered together
One box of each. Change strengths or quantities in the cart.
About IGF-1 LR3
What is IGF-1 LR3?
Overview
What is IGF-1 LR3?
IGF-1 LR3 is a recombinant 83-residue analogue of insulin-like growth factor 1. It carries an arginine substitution at position 3 and a 13-residue N-terminal extension, both of which reduce binding to IGF-binding proteins. Unlike the rest of this catalogue it is a recombinant protein rather than a synthesised peptide. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only.
IGF-1 LR3 at a glance
| Compound | IGF-1 LR3 |
|---|---|
| Also known as | Long R3 IGF-1, LR3 IGF-1, IGF-1 Long R3 |
| Classification | Recombinant 83-residue analogue of insulin-like growth factor 1 |
| CAS number | 946870-92-4 |
| Molecular weight | ~9111 g/mol |
| Sequence | 83 residues: Arg substituted at position 3, plus a 13-residue N-terminal extension |
| Purity | 99%+ by HPLC |
| Physical form | Lyophilised powder |
| Available strengths | 0.1 mg, 1 mg |
| Box quantity | 10 vials |
| Price from | $6.57 per vial ($65.71 per box) |
| Research status | Not a medicine. Supplied and used as a cell culture reagent. Prohibited in competitive sport under the WADA S2 category. |
| Documentation | Batch-specific third-party COA |
These are catalogue target specifications, not batch results. The 99%+ purity figure is the specification we buy to. The authoritative figures for any particular box are the ones printed on that box’s Certificate of Analysis, which is lot-specific. What research grade actually means explains the difference. Terms such as HPLC purity and net peptide content are explained in the peptide glossary.
We make no “third-party verified” claim for a batch unless the matching report is supplied with it. Ask for the current COA for the lot in stock before you order — we will send it.
Prices for every strength
Pricing
IGF-1 LR3 price per vial: 0.1mg and 1mg
IGF-1 LR3 starts at $6.57 per vial (£4.92), sold in boxes of 10 at $65.71. One box is the smallest order and there is no trade account or minimum spend. Larger volumes are negotiable.
| Strength | Per vial | Box of 10 |
|---|---|---|
| 0.1 mg | $6.57 £4.92 | $65.71 £49.23 |
| 1 mg | $17.53 £13.13 | $175.28 £131.32 |
Storage & reconstitution
Handling
How should IGF-1 LR3 be stored and reconstituted?
Sealed vials tolerate ambient temperature in transit and keep at −20 °C beyond that. Reconstitute slowly down the vial wall, swirl rather than shake, then refrigerate at 2–8 °C and aliquot before freezing.
Why each of those matters, and what a freeze–thaw cycle actually costs: peptide handling and storage reference. How long a mixed vial keeps: reconstituted peptide shelf life.
What it is researched for
Research Context
What is IGF-1 LR3 researched for?
Below is a plain-English summary of what published research has investigated, and what it has found. These are descriptions of research activity and published results. They are not claims about what IGF-1 LR3 does, and nothing here is a statement that it is safe or effective for any purpose.
Cell culture supplementation
This is its principal legitimate use. IGF-1 LR3 supports growth and survival of cultured cells and, because it resists binding proteins, stays available at a known concentration in a way native IGF-1 does not. In defined-medium embryo culture it outperformed native IGF-1 on early cleavage and gave the highest blastocyst cell counts. 2 Biotechnology manufacturers use it in production media for the same reason.
Escaping binding proteins
In serum, the overwhelming majority of native IGF-1 is bound to IGF-binding proteins and inactive. The Arg3 substitution and the 13-residue N-terminal extension sharply reduce that binding, measured at roughly three orders of magnitude lower affinity for the binding proteins than native IGF-1 itself. 2 That is the entire design rationale, and infusion work treats the analogue as pharmacologically distinct from the native hormone rather than as a stronger version of it. 1
IGF-1 receptor signalling
Used to study the receptor pathway controlling cell growth, protein synthesis and survival, without the confounding variable of binding-protein sequestration.
References
- 1Short-term infusion of LongR(3) insulin-like growth factor (IGF)-I decreases hepatic IGF-I mRNA but not IGF binding protein-3 mRNA expression in pigs. Gen Comp Endocrinol (2002). PMID 12030778
- 2Insulin-like growth factor I (IGF-I) and long R(3)IGF-I differently affect development and messenger ribonucleic acid abundance for IGF-binding proteins and type I IGF receptors in in vitro produced bovine embryos. Endocrinology (2001). PMID 11181549
Links open the record on PubMed or PubMed Central. These are citations to published research, not claims about this product.
Laboratory uses
Applications
Where IGF-1 LR3 is used in the laboratory
- IGF-1 receptor binding and signalling studies
- Cell culture media supplementation research
- IGF-binding protein interaction studies
- Comparative work against native IGF-1
Batch COA
Verification
Does IGF-1 LR3 come with a COA?
Yes — every box. Each batch of IGF-1 LR3 is analysed by an independent third-party laboratory, and the certificate is tied to the batch number on the vial label.
Example COA. You receive the certificate matching your own batch.
Questions & answers
Questions
IGF-1 LR3 questions, answered
Why is IGF-1 LR3 used instead of native IGF-1 in cell culture?
Native IGF-1 is bound and sequestered by IGF-binding proteins present in serum and secreted by many cell lines, which makes the effective concentration hard to control. The Arg3 substitution and N-terminal extension in LR3 sharply reduce that binding, so a known quantity stays available in the medium.
How much does IGF-1 LR3 cost?
IGF-1 LR3 starts at $6.57 per vial, sold in boxes of 10 vials at $65.71 per box (about £49.23). 2 strengths available: 0.1 mg, 1 mg. There is no minimum order.
Can I buy IGF-1 LR3 0.1mg vials in the UK?
Yes. IGF-1 LR3 0.1mg comes in boxes of 10 vials at $65.71 per box ($6.57 per vial, about £49.23 per box), sent tracked to UK addresses. There is no minimum order.
How is IGF-1 LR3 shipped to the UK and USA?
Tracked to the UK, USA, EU and worldwide, in plain packaging, dispatched within 1–2 working days. Country-by-country estimates are on the shipping page.
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