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C-terminal fragment of human growth hormone, residues 176-191
HGH Fragment 176-191
HGH Fragment 176-191 is the C-terminal fragment of human growth hormone, covering residues 176 to 191 of the 191-residue hormone. It contains none of the regions responsible for the full hormone's receptor binding. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only.
$80.28 (£63.42) per box of 10 vials · 2 mg, 5 mg, 10 mg, 15 mg
Overview
What is HGH Fragment 176-191?
HGH Fragment 176-191 is the C-terminal fragment of human growth hormone, covering residues 176 to 191 of the 191-residue hormone. It contains none of the regions responsible for the full hormone's receptor binding. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only.
HGH Fragment 176-191 at a glance
| Compound | HGH Fragment 176-191 |
|---|---|
| Also known as | HGH Frag 176-191, Growth hormone fragment 176-191, Frag 176-191 |
| Classification | C-terminal fragment of human growth hormone, residues 176-191 |
| CAS number | 66004-57-7 |
| Molecular formula | C78H125N23O23S2 |
| Molecular weight | 1817.1 g/mol |
| Sequence | hGH(176-191) |
| Purity | 99%+ by HPLC |
| Physical form | Lyophilised powder |
| Available strengths | 2 mg, 5 mg, 10 mg, 15 mg |
| Box quantity | 10 vials |
| Price from | $8.03 per vial ($80.28 per box) |
| Research status | Not approved anywhere. Preclinical. The research base is limited and older than that for its analogue AOD-9604. |
| Documentation | Batch-specific COA (Janoshik or Freedom Diagnostic) |
Nominal specifications. The authoritative figures for any given box are those printed on its batch COA.
Pricing
How much does HGH Fragment 176-191 cost?
HGH Fragment 176-191 starts at $8.03 per vial (£6.34), sold in boxes of 10 at $80.28. One box is the smallest order and there is no trade account or minimum spend. Larger volumes are negotiable.
| Strength | Per vial | Box of 10 |
|---|---|---|
| 2 mg | $8.03 £6.34 | $80.28 £63.42 |
| 5 mg | $11.06 £8.74 | $110.57 £87.35 |
| 10 mg | $17.00 £13.43 | $170.00 £134.30 |
| 15 mg | $21.00 £16.59 | $210.00 £165.90 |
Handling
How should HGH Fragment 176-191 be stored and reconstituted?
Full explanation of why each of these matters: peptide handling and storage reference.
Research Context
What is HGH Fragment 176-191 researched for?
Below is a plain-English summary of what published research has investigated, and what it has found. These are descriptions of research activity and published results. They are not claims about what HGH Fragment 176-191 does, and nothing here is a statement that it is safe or effective for any purpose.
Separating fat metabolism from growth
Growth hormone does two broadly separable things: it drives growth through IGF-1, and it influences fat breakdown. This fragment was isolated to test whether the second could be obtained without the first. 1
Adipocyte studies
Most published work uses fat cell culture and rodent models, examining lipolysis and markers of fat oxidation rather than whole-body outcomes. 1
Relationship to AOD-9604
AOD-9604 is this fragment with a tyrosine added at the N-terminus. Since AOD-9604 subsequently failed to meet its Phase 2 obesity endpoint, that result is directly relevant when interpreting research on the unmodified fragment. 2
References
- 1Reduction of cumulative body weight gain and adipose tissue mass in obese mice: response to chronic treatment with synthetic hGH 177-191 peptide. Biochem Mol Biol Int (1994). PMID 7987248
- 2Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. Int J Obes Relat Metab Disord (2001). PMID 11673763
Links open the record on PubMed or PubMed Central. These are citations to published research, not claims about this product.
Applications
Where HGH Fragment 176-191 is used in the laboratory
- Growth hormone structure-activity relationship research
- Lipid metabolism studies in adipocyte culture
- Comparative work against the tyrosine-modified AOD-9604 analogue
- Analytical characterisation of peptide fragments
Verification
Does HGH Fragment 176-191 come with a COA?
Yes — every box. Each batch of HGH Fragment 176-191 is analysed by Janoshik Analytical or Freedom Diagnostic. The certificate confirms identity by mass spectrometry and purity by HPLC, and is tied to the batch number printed on the vial label. You can ask to see it before you order.
Example COA. You receive the certificate matching your own batch.
Questions
HGH Fragment 176-191 questions, answered
Is HGH Fragment 176-191 the same as growth hormone?
No. Human growth hormone is a 191-residue protein. This fragment is the final 16 residues of that sequence and lacks the domains that bind the growth hormone receptor. It is studied as a discrete fragment, not as a substitute for or equivalent of the intact hormone.
How much does HGH Fragment 176-191 cost?
HGH Fragment 176-191 starts at $8.03 per vial, sold in boxes of 10 vials at $80.28 per box (about £63.42). 4 strengths available: 2 mg, 5 mg, 10 mg, 15 mg. There is no minimum order.
What purity is your HGH Fragment 176-191?
All batches test at 99%+ purity. Every box ships with a batch-specific Certificate of Analysis from Janoshik Analytical or Freedom Diagnostic, confirming identity by mass spectrometry and purity by HPLC.
Is there a minimum order for HGH Fragment 176-191?
No. You can order a single box of 10 vials. There is no trade account, bulk commitment or minimum spend.
How is HGH Fragment 176-191 shipped?
Tracked and in discreet, plain packaging, dispatched within 1–3 working days. Delivery estimates are UK 5–7 working days, EU 8–10, USA 5–8 and rest of world 10–12. Full detail is on the shipping page.
