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Synthetic heptapeptide, ACTH(4-10) analogue
Semax
Semax is a synthetic heptapeptide analogue of the ACTH(4-10) fragment, extended with a proline-glycine-proline tail that resists enzymatic breakdown. Despite the shared origin with adrenocorticotropic hormone, the fragment carries no corticotropic activity. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only.
$70.14 (£55.41) per box of 10 vials · 5 mg, 10 mg
Overview
What is Semax?
Semax is a synthetic heptapeptide analogue of the ACTH(4-10) fragment, extended with a proline-glycine-proline tail that resists enzymatic breakdown. Despite the shared origin with adrenocorticotropic hormone, the fragment carries no corticotropic activity. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only.
Semax at a glance
| Compound | Semax |
|---|---|
| Also known as | ACTH(4-10) Pro-Gly-Pro, Semax acetate |
| Classification | Synthetic heptapeptide, ACTH(4-10) analogue |
| CAS number | 80714-61-0 |
| Molecular formula | C37H51N9O10S |
| Molecular weight | 813.92 g/mol |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Purity | 99%+ by HPLC |
| Physical form | Lyophilised powder |
| Available strengths | 5 mg, 10 mg |
| Box quantity | 10 vials |
| Price from | $7.01 per vial ($70.14 per box) |
| Research status | Registered as a medicine in Russia. Not approved in the UK, EU or US. Most published research is Russian-language and has not been widely replicated. |
| Documentation | Batch-specific COA (Janoshik or Freedom Diagnostic) |
Nominal specifications. The authoritative figures for any given box are those printed on its batch COA.
Pricing
How much does Semax cost?
Semax starts at $7.01 per vial (£5.54), sold in boxes of 10 at $70.14. One box is the smallest order and there is no trade account or minimum spend. Larger volumes are negotiable.
| Strength | Per vial | Box of 10 |
|---|---|---|
| 5 mg | $7.01 £5.54 | $70.14 £55.41 |
| 10 mg | $8.51 £6.72 | $85.14 £67.26 |
Handling
How should Semax be stored and reconstituted?
Full explanation of why each of these matters: peptide handling and storage reference.
Research Context
What is Semax researched for?
Below is a plain-English summary of what published research has investigated, and what it has found. These are descriptions of research activity and published results. They are not claims about what Semax does, and nothing here is a statement that it is safe or effective for any purpose.
BDNF expression
The most-cited Semax finding is increased expression of brain-derived neurotrophic factor in rat hippocampus. BDNF supports the survival and growth of neurons, and this is the proposed basis for the cognitive research. 12
Neuroprotection models
Rodent stroke and cerebral ischaemia models are the main setting for Semax research, examining whether tissue damage is reduced when the peptide is administered after the event. 3
No hormonal activity
Although derived from ACTH, Semax covers residues 4 to 10, outside the region that stimulates the adrenal gland. It does not raise cortisol, which is precisely what allows it to be studied as a neuropeptide rather than a hormone analogue.
References
- 1Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochem Res (2005). PMID 16362768
- 2Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res (2006). PMID 16996037
- 3Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. Cell Mol Neurobiol (2010). PMID 19633950
Links open the record on PubMed or PubMed Central. These are citations to published research, not claims about this product.
Compare Semax
Applications
Where Semax is used in the laboratory
- ACTH fragment analogue pharmacology
- Neuropeptide stability and degradation research
- Comparative studies alongside Selank and related regulatory peptides
- Brain-derived neurotrophic factor expression studies in cell culture
Verification
Does Semax come with a COA?
Yes — every box. Each batch of Semax is analysed by Janoshik Analytical or Freedom Diagnostic. The certificate confirms identity by mass spectrometry and purity by HPLC, and is tied to the batch number printed on the vial label. You can ask to see it before you order.
Example COA. You receive the certificate matching your own batch.
Questions
Semax questions, answered
Does Semax act like ACTH?
No. Semax corresponds to residues 4 to 10 of adrenocorticotropic hormone, a region outside the portion responsible for stimulating the adrenal cortex. The fragment retains no corticotropic activity, which is why it is studied as a regulatory peptide rather than a hormone analogue.
How much does Semax cost?
Semax starts at $7.01 per vial, sold in boxes of 10 vials at $70.14 per box (about £55.41). 2 strengths available: 5 mg, 10 mg. There is no minimum order.
What purity is your Semax?
All batches test at 99%+ purity. Every box ships with a batch-specific Certificate of Analysis from Janoshik Analytical or Freedom Diagnostic, confirming identity by mass spectrometry and purity by HPLC.
Is there a minimum order for Semax?
No. You can order a single box of 10 vials. There is no trade account, bulk commitment or minimum spend.
How is Semax shipped?
Tracked and in discreet, plain packaging, dispatched within 1–3 working days. Delivery estimates are UK 5–7 working days, EU 8–10, USA 5–8 and rest of world 10–12. Full detail is on the shipping page.
