All products are for laboratory research purposes only. Not for human consumption.
Synthetic acetylated octapeptide, SNAP-25 N-terminal analogue
SNAP-8
SNAP-8 is a synthetic acetylated octapeptide studied as a cosmetic ingredient, built as an eight-residue elongation of the N-terminal sequence of SNAP-25. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only. It is also listed under its INCI name, acetyl octapeptide-3.
$74.71 (£59.02) per box of 10 vials · 10 mg
Select size
Boxes
- Sold in boxes of 10 vials. No minimum order and no trade account.
- Dispatched in 1–2 working days, tracked to the UK, USA, EU and worldwide.
- Batch-specific Certificate of Analysis from Janoshik or Freedom Diagnostic in every box.
- Photographed before it ships, so you see the exact order that leaves us.
Overview
What is SNAP-8?
SNAP-8 is a synthetic acetylated octapeptide studied as a cosmetic ingredient, built as an eight-residue elongation of the N-terminal sequence of SNAP-25. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only. It is also listed under its INCI name, acetyl octapeptide-3.
SNAP-8 at a glance
| Compound | SNAP-8 |
|---|---|
| Also known as | Acetyl Octapeptide-3, Acetyl Glutamyl Heptapeptide-1, snap 8 peptide, Acetyl Octapeptide-8 |
| Classification | Synthetic acetylated octapeptide, SNAP-25 N-terminal analogue |
| CAS number | 868844-74-0 |
| Molecular weight | ~1075 g/mol |
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (8 residues) |
| PubChem CID | 76283482 |
| Purity | 99%+ by HPLC |
| Physical form | Lyophilised powder |
| Available strengths | 10 mg |
| Box quantity | 10 vials |
| Price from | $7.47 per vial ($74.71 per box) |
| Research status | A cosmetic ingredient, not a medicine. Not approved as a therapeutic in any jurisdiction and not evaluated as one. Published work is largely formulation and in vitro research rather than clinical trial data. |
| Documentation | Batch-specific COA (Janoshik or Freedom Diagnostic) |
These are catalogue target specifications, not batch results. The 99%+ purity figure is the specification we buy to. The authoritative figures for any particular box are the ones printed on that box’s Certificate of Analysis, which is lot-specific.
We make no “third-party verified” claim for a batch unless the matching report is supplied with it. Ask for the current COA for the lot in stock before you order — we will send it.
Pricing
How much does SNAP-8 cost?
SNAP-8 starts at $7.47 per vial (£5.90), sold in boxes of 10 at $74.71. One box is the smallest order and there is no trade account or minimum spend. Larger volumes are negotiable.
| Strength | Per vial | Box of 10 |
|---|---|---|
| 10 mg | $7.47 £5.90 | $74.71 £59.02 |
Handling
How should SNAP-8 be stored and reconstituted?
Sealed vials tolerate ambient temperature in transit and keep at −20 °C beyond that. Reconstitute slowly down the vial wall, swirl rather than shake, then refrigerate at 2–8 °C and aliquot before freezing.
Why each of those matters, and what a freeze–thaw cycle actually costs: peptide handling and storage reference.
Research Context
What is SNAP-8 researched for?
Below is a plain-English summary of what published research has investigated, and what it has found. These are descriptions of research activity and published results. They are not claims about what SNAP-8 does, and nothing here is a statement that it is safe or effective for any purpose.
SNARE complex assembly
SNAP-25 is one of three proteins that assemble into the SNARE complex, the machinery that docks vesicles to a membrane before their contents are released. SNAP-8 reproduces the N-terminal end of that protein, and the research question is whether a short peptide resembling that end can compete with the full protein during assembly. The N-terminal peptide of SNAP-25 is itself an established binding site in assembly research, which is what makes that a coherent question rather than a guess. 1
Comparison with argireline
Argireline, INCI acetyl hexapeptide-8 and formerly acetyl hexapeptide-3, is the six-residue version of the same idea and is by far the more studied of the two. Its sequence is Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2 and the original characterisation attributed its effect to interference with formation or stability of the SNARE complex. 2 SNAP-8 is that sequence with Ala-Asp added. The pair is frequently compared precisely because they differ only in length, which isolates what the extension changes about binding.
Formulation and stability research
Most of the published work on peptides of this class concerns delivery rather than mechanism: whether a charged, water-soluble peptide of this size remains intact in a formulation, and whether it reaches anything relevant when applied topically. A 2025 review of the hexapeptide concludes that its hydrophilic character and size limit passage through the stratum corneum, that emulsion strategies have been explored to improve delivery, and that whether the peptide reaches the neuromuscular junction at all remains uncertain. 3 Those questions are unresolved and are the main reason the cosmetic literature on this class is contested.
References
- 1Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE complex assembly in exocytosis. Elife (2022). PMID 36173100
- 2A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci (2002). PMID 18498523
- 3Acetyl Hexapeptide-8 in Cosmeceuticals - A Review of Skin Permeability and Efficacy. Int J Mol Sci (2025). PMID 40565185
Links open the record on PubMed or PubMed Central. These are citations to published research, not claims about this product.
Applications
Where SNAP-8 is used in the laboratory
- SNARE complex assembly and vesicle-docking studies
- Comparative work against the shorter hexapeptide argireline (acetyl hexapeptide-3)
- Topical formulation and peptide-stability research
- Dermal cell culture models
Verification
Does SNAP-8 come with a COA?
Yes — every box. Each batch of SNAP-8 is analysed by Janoshik Analytical or Freedom Diagnostic, and the certificate is tied to the batch number on the vial label.
Example COA. You receive the certificate matching your own batch.
Questions
SNAP-8 questions, answered
What is SNAP-8 peptide?
An eight-residue acetylated peptide whose sequence mimics the N-terminal end of SNAP-25, one of the three proteins that form the SNARE complex. The research interest is in whether a peptide resembling that end can compete with the real protein during complex assembly. It is a cosmetic ingredient rather than a medicine, and is supplied here for laboratory research only.
How does SNAP-8 differ from argireline?
Two more residues. Argireline is acetyl hexapeptide-3, six residues of the same SNAP-25 N-terminal sequence; SNAP-8 extends that to eight. The two are routinely compared for exactly that reason, since the pair isolates what the additional length changes.
How much does SNAP-8 cost?
SNAP-8 starts at $7.47 per vial, sold in boxes of 10 vials at $74.71 per box (about £59.02). 1 strength available: 10 mg. There is no minimum order.
How is SNAP-8 shipped?
Tracked, in plain packaging, dispatched within 1–2 working days. Country-by-country estimates are on the shipping page.
