All products are for laboratory research purposes only. Not for human consumption.
Synthetic triple incretin receptor agonist peptide
Retatrutide
Retatrutide (development code LY3437943) is a synthetic single-molecule agonist at three receptors: GIP, GLP-1 and glucagon. The peptide backbone carries a C20 diacid fatty-acid conjugate that extends its plasma half-life through albumin binding. Supplied as a lyophilised powder, boxed in tens, for laboratory research use only.
$81.57 (£64.44) per box of 10 vials · 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg
Overview
What is Retatrutide?
Retatrutide (development code LY3437943) is a synthetic single-molecule agonist at three receptors: GIP, GLP-1 and glucagon. The peptide backbone carries a C20 diacid fatty-acid conjugate that extends its plasma half-life through albumin binding. Supplied as a lyophilised powder, boxed in tens, for laboratory research use only.
Retatrutide at a glance
| Compound | Retatrutide |
|---|---|
| Also known as | LY3437943, Reta, triple agonist peptide, GGG tri-agonist |
| Classification | Synthetic triple incretin receptor agonist peptide |
| CAS number | 2381089-83-2 |
| Molecular weight | ~4731 g/mol |
| Sequence | 39-residue backbone with a C20 diacid fatty-acid conjugate |
| Purity | 99%+ by HPLC |
| Physical form | Lyophilised powder |
| Available strengths | 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg |
| Box quantity | 10 vials |
| Price from | $8.16 per vial ($81.57 per box) |
| Research status | Investigational. In late-stage clinical trials with Eli Lilly. Not approved for any use in any country. |
| Documentation | Batch-specific COA (Janoshik or Freedom Diagnostic) |
Nominal specifications. The authoritative figures for any given box are those printed on its batch COA.
Pricing
How much does Retatrutide cost?
Retatrutide starts at $8.16 per vial (£6.45), sold in boxes of 10 at $81.57. One box is the smallest order and there is no trade account or minimum spend. Larger volumes are negotiable.
| Strength | Per vial | Box of 10 |
|---|---|---|
| 5 mg | $8.16 £6.45 | $81.57 £64.44 |
| 10 mg | $9.83 £7.77 | $98.28 £77.64 |
| 15 mg | $11.87 £9.38 | $118.71 £93.78 |
| 20 mg | $12.99 £10.26 | $129.85 £102.58 |
| 30 mg | $16.14 £12.75 | $161.42 £127.52 |
| 40 mg | $18.93 £14.95 | $189.28 £149.53 |
| 60 mg | $25.43 £20.09 | $254.28 £200.88 |
Handling
How should Retatrutide be stored and reconstituted?
Full explanation of why each of these matters: peptide handling and storage reference.
Research Context
What is Retatrutide researched for?
Below is a plain-English summary of what published research has investigated, and what it has found. These are descriptions of research activity and published results. They are not claims about what Retatrutide does, and nothing here is a statement that it is safe or effective for any purpose.
Three receptors at once
Retatrutide activates the GIP, GLP-1 and glucagon receptors from a single molecule. The reasoning is that GLP-1 reduces appetite, GIP appears to improve how that is tolerated, and glucagon raises energy expenditure, so engaging all three may achieve more than any one alone. 1
Metabolic and body-weight research
Published Phase 2 trial results reported average body-weight reductions larger than those seen with single or dual agonists over comparable periods. Those are supervised clinical trial outcomes in patients, not statements about research-grade material. 1
Benchmarking against other incretins
As the most complete incretin agonist in development, retatrutide is routinely used as a comparator in receptor-binding and potency assays alongside tirzepatide and semaglutide.
References
- 1Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial. N Engl J Med (2023). PMID 37366315
Links open the record on PubMed or PubMed Central. These are citations to published research, not claims about this product.
Compare Retatrutide
Applications
Where Retatrutide is used in the laboratory
- Incretin receptor pharmacology and multi-receptor agonist binding studies
- Comparative in vitro receptor selectivity and potency profiling
- Peptide conjugate stability and formulation research
- Analytical characterisation of long-acting fatty-acylated peptides
Verification
Does Retatrutide come with a COA?
Yes — every box. Each batch of Retatrutide is analysed by Janoshik Analytical or Freedom Diagnostic. The certificate confirms identity by mass spectrometry and purity by HPLC, and is tied to the batch number printed on the vial label. You can ask to see it before you order.
Example COA. You receive the certificate matching your own batch.
Questions
Retatrutide questions, answered
What does triple agonist mean?
It means a single molecule binds and activates three distinct receptors, here the GIP, GLP-1 and glucagon receptors. This contrasts with single agonists such as semaglutide (GLP-1 only) or dual agonists such as tirzepatide (GIP and GLP-1).
How much does Retatrutide cost?
Retatrutide starts at $8.16 per vial, sold in boxes of 10 vials at $81.57 per box (about £64.44). 7 strengths available: 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg. There is no minimum order.
What purity is your Retatrutide?
All batches test at 99%+ purity. Every box ships with a batch-specific Certificate of Analysis from Janoshik Analytical or Freedom Diagnostic, confirming identity by mass spectrometry and purity by HPLC.
Is there a minimum order for Retatrutide?
No. You can order a single box of 10 vials. There is no trade account, bulk commitment or minimum spend.
How is Retatrutide shipped?
Tracked and in discreet, plain packaging, dispatched within 1–3 working days. Delivery estimates are UK 5–7 working days, EU 8–10, USA 5–8 and rest of world 10–12. Full detail is on the shipping page.
