All products are for laboratory research purposes only. Not for human consumption.
Synthetic GHRH(1-29) N-terminal fragment analogue
Sermorelin
Sermorelin is a synthetic 29-residue peptide corresponding to the N-terminal fragment of growth-hormone-releasing hormone — the shortest portion of the parent hormone that retains full activity at the GHRH receptor. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only. It is also written as GRF(1-29) and GHRH(1-29), and the sermorelin peptide sold for research is the same compound under any of those names.
$75.00 (£59.25) per box of 10 vials · 5 mg, 10 mg
Select size
Boxes
- Sold in boxes of 10 vials. No minimum order and no trade account.
- Dispatched in 1–2 working days, tracked to the UK, USA, EU and worldwide.
- Batch-specific Certificate of Analysis from Janoshik or Freedom Diagnostic in every box.
- Photographed before it ships, so you see the exact order that leaves us.
Overview
What is Sermorelin?
Sermorelin is a synthetic 29-residue peptide corresponding to the N-terminal fragment of growth-hormone-releasing hormone — the shortest portion of the parent hormone that retains full activity at the GHRH receptor. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only. It is also written as GRF(1-29) and GHRH(1-29), and the sermorelin peptide sold for research is the same compound under any of those names.
Sermorelin at a glance
| Compound | Sermorelin |
|---|---|
| Also known as | GRF(1-29), Sermorelin acetate, GHRH(1-29), sermorelin peptide |
| Classification | Synthetic GHRH(1-29) N-terminal fragment analogue |
| CAS number | 86168-78-7 |
| Molecular weight | ~3358 g/mol |
| Sequence | 29-residue N-terminal fragment of GHRH (YADAIFTNSYRKVLGQLSARKLLQDIMSR) |
| PubChem CID | 16132413 |
| Purity | 99%+ by HPLC |
| Physical form | Lyophilised powder |
| Available strengths | 5 mg, 10 mg |
| Box quantity | 10 vials |
| Price from | $7.50 per vial ($75.00 per box) |
| Research status | Formerly approved as a licensed medicine in the United States under the name Geref; discontinued commercially in 2008. Not licensed in the UK. Prohibited in competitive sport under the WADA S2 category covering growth hormone releasing factors. |
| Documentation | Batch-specific COA (Janoshik or Freedom Diagnostic) |
These are catalogue target specifications, not batch results. The 99%+ purity figure is the specification we buy to. The authoritative figures for any particular box are the ones printed on that box’s Certificate of Analysis, which is lot-specific.
We make no “third-party verified” claim for a batch unless the matching report is supplied with it. Ask for the current COA for the lot in stock before you order — we will send it.
Pricing
How much does Sermorelin cost?
Sermorelin starts at $7.50 per vial (£5.93), sold in boxes of 10 at $75.00. One box is the smallest order and there is no trade account or minimum spend. Larger volumes are negotiable.
| Strength | Per vial | Box of 10 |
|---|---|---|
| 5 mg | $7.50 £5.93 | $75.00 £59.25 |
| 10 mg | $10.00 £7.90 | $100.00 £79.00 |
Handling
How should Sermorelin be stored and reconstituted?
Sealed vials tolerate ambient temperature in transit and keep at −20 °C beyond that. Reconstitute slowly down the vial wall, swirl rather than shake, then refrigerate at 2–8 °C and aliquot before freezing.
Why each of those matters, and what a freeze–thaw cycle actually costs: peptide handling and storage reference.
Research Context
What is Sermorelin researched for?
Below is a plain-English summary of what published research has investigated, and what it has found. These are descriptions of research activity and published results. They are not claims about what Sermorelin does, and nothing here is a statement that it is safe or effective for any purpose.
GHRH receptor pharmacology
Sermorelin is the 1-29 N-terminal fragment of growth-hormone-releasing hormone, amidated at the C-terminus. Deletion work on the parent hormone mapped where the activity actually sits: shortening hGRF to the 1-29 fragment leaves roughly half the potency of the full-length hormone, fragments as short as 1-21 remain active though at very low potency, and bioactivity only disappears once the chain is cut back to 1-19, with the minimal fully intrinsic core falling in the 3-21 region. 1 That makes 1-29 the shortest fragment still practical as a full agonist rather than an arbitrary cut, which is why it is the length carried forward into the rest of the analogue family.
Short half-life as a research property
Sermorelin retains the Ala2-Asp3 bond of the parent hormone and is cleaved there by dipeptidyl peptidase-4 at essentially the same rate as full-length GRF, which is what gives the unmodified peptide a plasma half-life measured in minutes. 2 That was a practical limitation in its clinical era and is a useful property in a laboratory setting, where a short-acting agonist separates an acute receptor response from the effects of sustained exposure. It is also the specific bond that the later analogues in this family were designed around.
Comparative GHRH work
It is routinely run against longer-acting analogues in the same family: tesamorelin, which is full-length and modified, and the CJC-1295 forms, which are the same 1-29 fragment with substitutions and in one case an albumin-binding group. Because all of them act at the same receptor, the comparison isolates what changing exposure over time does rather than what the peptide does at the receptor. Direct comparisons of the 1-29 fragment against the full-length hormone report differences in how repeatable the response is on re-exposure, not only in potency. 3
References
- 1Synthesis and in vitro bioactivity of C-terminal deleted analogs of human growth hormone-releasing factor. Biochem Biophys Res Commun (1984). PMID 6435620
- 2Kinetics of dipeptidyl peptidase IV proteolysis of growth hormone-releasing factor and analogs. Biochim Biophys Acta (1992). PMID 1353684
- 3A comparison of the biological activities of authentic rat GRF(1-43)OH with the analogue rat GRF(1-29)NH2. Can J Physiol Pharmacol (1991). PMID 1829020
Links open the record on PubMed or PubMed Central. These are citations to published research, not claims about this product.
Compare Sermorelin
Applications
Where Sermorelin is used in the laboratory
- GHRH receptor (GHRH-R) binding and signalling studies
- Somatotroph cell culture research
- Comparative work against full-length and long-acting GHRH analogues such as tesamorelin and the CJC-1295 family
- Peptide fragment structure-activity research, where the question is how much of a hormone can be removed before activity is lost
Verification
Does Sermorelin come with a COA?
Yes — every box. Each batch of Sermorelin is analysed by Janoshik Analytical or Freedom Diagnostic, and the certificate is tied to the batch number on the vial label.
Example COA. You receive the certificate matching your own batch.
Questions
Sermorelin questions, answered
What is sermorelin peptide?
Sermorelin is the first 29 amino acids of growth-hormone-releasing hormone, synthesised as a standalone peptide. Truncating GHRH to this length keeps its activity at the receptor; shortening it further does not. That makes it the reference fragment in GHRH structure-activity work, and it is supplied here as laboratory research material only.
Is sermorelin a peptide?
Yes, and an unmodified one — a plain 29-residue chain with no fatty-acid conjugate, no substitutions and nothing attached to extend its half-life. That is what separates it from tesamorelin and from the CJC-1295 family, which are the same idea with modifications bolted on.
How is sermorelin different from tesamorelin?
Length and modification. Sermorelin is the unmodified 1-29 fragment; tesamorelin is a full-length 1-44 analogue carrying a trans-3-hexenoyl group that blocks the enzyme which would otherwise clear it within minutes. Both act at the same receptor, so the comparison in the literature is about exposure over time rather than about what happens at the receptor itself.
How much does Sermorelin cost?
Sermorelin starts at $7.50 per vial, sold in boxes of 10 vials at $75.00 per box (about £59.25). 2 strengths available: 5 mg, 10 mg. There is no minimum order.
How is Sermorelin shipped?
Tracked, in plain packaging, dispatched within 1–2 working days. Country-by-country estimates are on the shipping page.
