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Small-molecule quinolinium inhibitor of nicotinamide N-methyltransferase
5-Amino-1MQ
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase, the enzyme that methylates nicotinamide and by doing so removes it from the salvage pathway that regenerates NAD+. It is a quinolinium compound, not a peptide, and is catalogued here because it is ordered alongside the metabolic peptides rather than because it shares their structure. Supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only.
$65.85 (£52.02) per box of 10 vials · 5 mg, 10 mg, 50 mg
Select size
Boxes
- Sold in boxes of 10 vials. No minimum order and no trade account.
- Dispatched in 1–2 working days, tracked to the UK, USA, EU and worldwide.
- Batch-specific Certificate of Analysis from Janoshik or Freedom Diagnostic in every box.
- Photographed before it ships, so you see the exact order that leaves us.
Overview
What is 5-Amino-1MQ?
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase, the enzyme that methylates nicotinamide and by doing so removes it from the salvage pathway that regenerates NAD+. It is a quinolinium compound, not a peptide, and is catalogued here because it is ordered alongside the metabolic peptides rather than because it shares their structure. Supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only.
5-Amino-1MQ at a glance
| Compound | 5-Amino-1MQ |
|---|---|
| Also known as | 5-amino-1-methylquinolinium, 5A1MQ, 5 amino 1MQ, NNMT inhibitor |
| Classification | Small-molecule quinolinium inhibitor of nicotinamide N-methyltransferase |
| CAS number | 685079-15-6 |
| Molecular formula | C10H11N2+ |
| Molecular weight | 159.21 g/mol |
| PubChem CID | 950107 |
| Purity | 99%+ by HPLC |
| Physical form | Lyophilised powder |
| Available strengths | 5 mg, 10 mg, 50 mg |
| Box quantity | 10 vials |
| Price from | $6.59 per vial ($65.85 per box) |
| Research status | 5-Amino-1MQ inhibits nicotinamide N-methyltransferase. The interest in it is indirect: NNMT consumes nicotinamide, so inhibiting the enzyme is one proposed route to raising NAD+ without supplying a precursor. The work is preclinical, mostly cell and rodent models, and the field is young. |
| Documentation | Batch-specific COA (Janoshik or Freedom Diagnostic) |
These are catalogue target specifications, not batch results. The 99%+ purity figure is the specification we buy to. The authoritative figures for any particular box are the ones printed on that box’s Certificate of Analysis, which is lot-specific.
We make no “third-party verified” claim for a batch unless the matching report is supplied with it. Ask for the current COA for the lot in stock before you order — we will send it.
Pricing
How much does 5-Amino-1MQ cost?
5-Amino-1MQ starts at $6.59 per vial (£5.21), sold in boxes of 10 at $65.85. One box is the smallest order and there is no trade account or minimum spend. Larger volumes are negotiable.
| Strength | Per vial | Box of 10 |
|---|---|---|
| 5 mg | $6.59 £5.21 | $65.85 £52.02 |
| 10 mg | $8.04 £6.35 | $80.42 £63.53 |
| 50 mg | $9.57 £7.56 | $95.71 £75.61 |
Handling
How should 5-Amino-1MQ be stored and reconstituted?
Sealed vials tolerate ambient temperature in transit and keep at −20 °C beyond that. Reconstitute slowly down the vial wall, swirl rather than shake, then refrigerate at 2–8 °C and aliquot before freezing.
Why each of those matters, and what a freeze–thaw cycle actually costs: peptide handling and storage reference.
Research Context
What is 5-Amino-1MQ researched for?
Below is a plain-English summary of what published research has investigated, and what it has found. These are descriptions of research activity and published results. They are not claims about what 5-Amino-1MQ does, and nothing here is a statement that it is safe or effective for any purpose.
The enzyme and why it is a target
NNMT methylates nicotinamide, diverting it from the salvage pathway that regenerates NAD+. Elevated NNMT expression has been reported in adipose tissue and linked to metabolic pathways, which is the basis for treating the enzyme as a therapeutic target rather than a housekeeping one. 1
Where the field has reached
Reviews of NNMT inhibitor development describe a field moving from tool compounds toward candidates that might be tested clinically, while noting that none has yet made that transition. 2
What is not established
No NNMT inhibitor has completed a human trial. Whether inhibiting the enzyme raises NAD+ meaningfully in humans, and whether that produces the metabolic effects seen in rodents, is untested.
References
- 1Exploring NNMT: from metabolic pathways to therapeutic targets. Arch Pharm Res (2024). PMID 39604638
- 2Emerging opportunities for nicotinamide N-methyltransferase (NNMT) inhibitor clinical translation. Trends Pharmacol Sci (2026). PMID 42067476
Links open the record on PubMed or PubMed Central. These are citations to published research, not claims about this product.
Applications
Where 5-Amino-1MQ is used in the laboratory
- NNMT enzyme inhibition studies, the direct target
- NAD+ salvage pathway research, since inhibiting NNMT is one proposed route to raising cellular NAD+ without supplying a precursor
- Adipocyte metabolism models, the tissue in which NNMT inhibition has been examined most
- Comparative work alongside NAD+ itself, which is in this catalogue
Verification
Does 5-Amino-1MQ come with a COA?
Yes — every box. Each batch of 5-Amino-1MQ is analysed by Janoshik Analytical or Freedom Diagnostic, and the certificate is tied to the batch number on the vial label.
Example COA. You receive the certificate matching your own batch.
Questions
5-Amino-1MQ questions, answered
Is 5-Amino-1MQ a peptide?
No. It is a small-molecule quinolinium salt weighing about 159 g/mol, roughly a twentieth of the smallest peptide in this catalogue. It appears here because researchers ordering metabolic peptides frequently order it in the same box, not because it belongs to the same chemical class. We would rather say that plainly than let the catalogue imply otherwise.
How much does 5-Amino-1MQ cost?
5-Amino-1MQ starts at $6.59 per vial, sold in boxes of 10 vials at $65.85 per box (about £52.02). 3 strengths available: 5 mg, 10 mg, 50 mg. There is no minimum order.
How is 5-Amino-1MQ shipped?
Tracked, in plain packaging, dispatched within 1–2 working days. Country-by-country estimates are on the shipping page.
