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Synthetic GLP-1 receptor agonist peptide
Semaglutide
Semaglutide is a synthetic 31-residue analogue of glucagon-like peptide-1 (GLP-1). Two substitutions in the backbone and a C18 diacid attached through an AEEA linker slow enzymatic breakdown and promote albumin binding. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only.
$60.00 (£47.40) per box of 10 vials · 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg
Overview
What is Semaglutide?
Semaglutide is a synthetic 31-residue analogue of glucagon-like peptide-1 (GLP-1). Two substitutions in the backbone and a C18 diacid attached through an AEEA linker slow enzymatic breakdown and promote albumin binding. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only.
Semaglutide at a glance
| Compound | Semaglutide |
|---|---|
| Also known as | NN9535, GLP-1 analogue, semaglutide sodium |
| Classification | Synthetic GLP-1 receptor agonist peptide |
| CAS number | 910463-68-2 |
| Molecular formula | C187H291N45O59 |
| Molecular weight | 4113.58 g/mol |
| Sequence | 31-residue GLP-1 analogue, Aib8 and Arg34 substituted, C18 diacid attached via an AEEA linker |
| Purity | 99%+ by HPLC |
| Physical form | Lyophilised powder |
| Available strengths | 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg |
| Box quantity | 10 vials |
| Price from | $6.00 per vial ($60.00 per box) |
| Research status | An approved prescription medicine in the UK and many other countries. Supply outside the regulated pharmaceutical chain is unlawful. Included here strictly as a laboratory reference material. |
| Documentation | Batch-specific COA (Janoshik or Freedom Diagnostic) |
Nominal specifications. The authoritative figures for any given box are those printed on its batch COA.
Pricing
How much does Semaglutide cost?
Semaglutide starts at $6.00 per vial (£4.74), sold in boxes of 10 at $60.00. One box is the smallest order and there is no trade account or minimum spend. Larger volumes are negotiable.
| Strength | Per vial | Box of 10 |
|---|---|---|
| 2 mg | $6.00 £4.74 | $60.00 £47.40 |
| 5 mg | $7.23 £5.71 | $72.28 £57.10 |
| 10 mg | $7.97 £6.30 | $79.71 £62.97 |
| 15 mg | $8.53 £6.74 | $85.28 £67.37 |
| 20 mg | $8.90 £7.03 | $89.00 £70.31 |
| 30 mg | $9.83 £7.77 | $98.28 £77.64 |
| 40 mg | $12.43 £9.82 | $124.28 £98.18 |
| 50 mg | $13.36 £10.55 | $133.57 £105.52 |
Handling
How should Semaglutide be stored and reconstituted?
Full explanation of why each of these matters: peptide handling and storage reference.
Research Context
What is Semaglutide researched for?
Below is a plain-English summary of what published research has investigated, and what it has found. These are descriptions of research activity and published results. They are not claims about what Semaglutide does, and nothing here is a statement that it is safe or effective for any purpose.
GLP-1 receptor activation
Semaglutide binds the GLP-1 receptor, found on pancreatic cells and on brain regions involved in appetite regulation. Activation increases insulin release when glucose is high and slows gastric emptying. 1
Half-life engineering
Native GLP-1 survives about two minutes; semaglutide lasts roughly a week. Two changes achieve that: an Aib substitution that blocks the enzyme DPP-4 from cutting the peptide, and a fatty acid chain that parks the molecule on albumin. It is one of the clearest worked examples of peptide half-life extension in the literature.
Metabolic research
A large clinical literature covers effects on blood glucose and body weight. Those trials used pharmaceutical-grade product under medical supervision, which is a materially different context from research-grade material. 1
References
- 1Once-Weekly Semaglutide in Adults with Overweight or Obesity (the STEP 1 trial). N Engl J Med (2021). PMID 33567185
Links open the record on PubMed or PubMed Central. These are citations to published research, not claims about this product.
Compare Semaglutide
Applications
Where Semaglutide is used in the laboratory
- GLP-1 receptor binding and signalling studies
- Comparative potency profiling against native GLP-1 and other analogues
- Albumin-binding and half-life extension research on acylated peptides
- Analytical characterisation of long-acting incretin analogues
Verification
Does Semaglutide come with a COA?
Yes — every box. Each batch of Semaglutide is analysed by Janoshik Analytical or Freedom Diagnostic. The certificate confirms identity by mass spectrometry and purity by HPLC, and is tied to the batch number printed on the vial label. You can ask to see it before you order.
Example COA. You receive the certificate matching your own batch.
Questions
Semaglutide questions, answered
Why is semaglutide described as long-acting?
Native GLP-1 is cleared within minutes by dipeptidyl peptidase-4. Semaglutide carries an aminoisobutyric acid substitution at position 8 that blocks that cleavage site, plus a C18 diacid chain that binds serum albumin. Together these extend the circulating half-life from minutes to roughly a week.
How much does Semaglutide cost?
Semaglutide starts at $6.00 per vial, sold in boxes of 10 vials at $60.00 per box (about £47.40). 8 strengths available: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg. There is no minimum order.
What purity is your Semaglutide?
All batches test at 99%+ purity. Every box ships with a batch-specific Certificate of Analysis from Janoshik Analytical or Freedom Diagnostic, confirming identity by mass spectrometry and purity by HPLC.
Is there a minimum order for Semaglutide?
No. You can order a single box of 10 vials. There is no trade account, bulk commitment or minimum spend.
How is Semaglutide shipped?
Tracked and in discreet, plain packaging, dispatched within 1–3 working days. Delivery estimates are UK 5–7 working days, EU 8–10, USA 5–8 and rest of world 10–12. Full detail is on the shipping page.
