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All products are for laboratory research purposes only. Not for human consumption.

Synthetic tetrapeptide

Epitalon

Epitalon is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, developed as a short synthetic counterpart to the peptide fraction originally isolated from the pineal gland. At 390 g/mol it is among the smallest peptides in the catalog. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only.

From $7.97 per vial · £6.30

$79.71 (£62.97) per box of 10 vials · 10 mg, 40 mg, 50 mg

Vial of Epitalon research peptide, supplied in boxes of 10

Overview

What is Epitalon?

Epitalon is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, developed as a short synthetic counterpart to the peptide fraction originally isolated from the pineal gland. At 390 g/mol it is among the smallest peptides in the catalog. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only.

Laboratory research use onlyNobelPepLab supplies Epitalon strictly for in vitro and laboratory research. We do not provide dosing guidance, do not make health claims, and do not supply products for human or veterinary use.

Epitalon at a glance

CompoundEpitalon
Also known asEpithalon, Epithalamin, AEDG peptide, Epitalone
ClassificationSynthetic tetrapeptide
CAS number307297-39-8
Molecular formulaC14H22N4O9
Molecular weight390.35 g/mol
SequenceAla-Glu-Asp-Gly
Purity99%+ by HPLC
Physical formLyophilised powder
Available strengths10 mg, 40 mg, 50 mg
Box quantity10 vials
Price from$7.97 per vial ($79.71 per box)
Research statusNot approved in the UK, EU or US. Human data is limited to small Russian studies, several decades old, that have not been independently replicated.
DocumentationBatch-specific COA (Janoshik or Freedom Diagnostic)

Nominal specifications. The authoritative figures for any given box are those printed on its batch COA.

Pricing

How much does Epitalon cost?

Epitalon starts at $7.97 per vial (£6.30), sold in boxes of 10 at $79.71. One box is the smallest order and there is no trade account or minimum spend. Larger volumes are negotiable.

Epitalon price by strength. Billed in USD; GBP shown as an indicative conversion. Each box contains 10 vials.
StrengthPer vialBox of 10
10 mg$7.97 £6.30$79.71 £62.97
40 mg$14.21 £11.23$142.14 £112.29
50 mg$15.50 £12.25$155.00 £122.45

Handling

How should Epitalon be stored and reconstituted?

Lyophilised storage. Sealed vials are stable at room temperature for short periods during transit. For longer-term storage keep at −20 °C, protected from light and moisture.
Reconstitution. Bacteriostatic or sterile water is introduced slowly down the inside wall of the vial. Do not inject the stream directly into the powder and do not shake.
Dissolving. Swirl gently until clear. Peptides are shear-sensitive; vigorous agitation can degrade the compound.
After reconstitution. Refrigerate at 2–8 °C. Reconstituted peptide has a materially shorter working life than the lyophilised form.
Freeze–thaw. Repeated cycles degrade peptides. Aliquot before freezing where a protocol requires multiple uses.

Research Context

What is Epitalon researched for?

Below is a plain-English summary of what published research has investigated, and what it has found. These are descriptions of research activity and published results. They are not claims about what Epitalon does, and nothing here is a statement that it is safe or effective for any purpose.

Research status Not approved in the UK, EU or US. Human data is limited to small Russian studies, several decades old, that have not been independently replicated.

Telomerase research

The best-known claim is that Epitalon increases telomerase activity, the enzyme maintaining the protective caps on chromosome ends. Supporting evidence comes from a small number of cell culture studies and has not been broadly reproduced by independent groups. 1

Pineal and circadian biology

Epitalon is the synthetic stand-in for a pineal gland extract, and much of the original work examined melatonin rhythms and age-related changes in that gland.

Peptide bioregulator theory

It is the flagship compound of a Russian research tradition proposing that very short peptides act as direct gene regulators. That framework is not widely accepted outside those groups, which is worth knowing when reading the Epitalon literature.

References

  1. 1Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology (2025). PMID 40908429

Links open the record on PubMed or PubMed Central. These are citations to published research, not claims about this product.

Read this before citing any of the abovePreclinical means the work was done in cells or animals. Results in those systems very often fail to reproduce in humans. NobelPepLab supplies Epitalon for laboratory research only, does not provide dosing guidance, and does not supply products for human or veterinary use.

Applications

Where Epitalon is used in the laboratory

  • Telomerase expression studies in cell culture
  • Pineal peptide biology and circadian regulation research
  • Short-peptide stability and solubility characterisation
  • Comparative studies against longer peptide bioregulators

Verification

Does Epitalon come with a COA?

Yes — every box. Each batch of Epitalon is analysed by Janoshik Analytical or Freedom Diagnostic. The certificate confirms identity by mass spectrometry and purity by HPLC, and is tied to the batch number printed on the vial label. You can ask to see it before you order.

HPLC chromatogram with the quantified purity figure
Mass spectrometry confirming molecular weight against the theoretical value
Batch or lot reference matching the vial label
Laboratory letterhead, test date and analyst signature
Example Certificate of Analysis issued by Janoshik Analytical

Example COA. You receive the certificate matching your own batch.

Questions

Epitalon questions, answered

What is the difference between Epitalon and Epithalamin?

Epithalamin is the original peptide extract prepared from bovine pineal gland, a mixture rather than a single defined compound. Epitalon is the synthetic tetrapeptide Ala-Glu-Asp-Gly identified from that work. Only the synthetic form has a defined sequence and molecular weight that a COA can verify, which is what we supply.

How much does Epitalon cost?

Epitalon starts at $7.97 per vial, sold in boxes of 10 vials at $79.71 per box (about £62.97). 3 strengths available: 10 mg, 40 mg, 50 mg. There is no minimum order.

What purity is your Epitalon?

All batches test at 99%+ purity. Every box ships with a batch-specific Certificate of Analysis from Janoshik Analytical or Freedom Diagnostic, confirming identity by mass spectrometry and purity by HPLC.

Is there a minimum order for Epitalon?

No. You can order a single box of 10 vials. There is no trade account, bulk commitment or minimum spend.

How is Epitalon shipped?

Tracked and in discreet, plain packaging, dispatched within 1–3 working days. Delivery estimates are UK 5–7 working days, EU 8–10, USA 5–8 and rest of world 10–12. Full detail is on the shipping page.