All products are for laboratory research purposes only. Not for human consumption.
Cyclic lactam heptapeptide melanocortin receptor agonist
PT-141
PT-141 is a cyclic lactam heptapeptide and a metabolite of Melanotan II, differing from it by a free carboxylic acid at the C-terminus in place of the amide. That single change shifts its receptor selectivity profile. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only.
$90.85 (£71.77) per box of 10 vials · 10 mg
Overview
What is PT-141?
PT-141 is a cyclic lactam heptapeptide and a metabolite of Melanotan II, differing from it by a free carboxylic acid at the C-terminus in place of the amide. That single change shifts its receptor selectivity profile. It is supplied as a lyophilised powder in sealed vials, boxed in tens, for laboratory research use only.
PT-141 at a glance
| Compound | PT-141 |
|---|---|
| Also known as | Bremelanotide, PT141, PT 141 |
| Classification | Cyclic lactam heptapeptide melanocortin receptor agonist |
| CAS number | 189691-06-3 |
| Molecular formula | C50H68N14O10 |
| Molecular weight | 1025.16 g/mol |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| Purity | 99%+ by HPLC |
| Physical form | Lyophilised powder |
| Available strengths | 10 mg |
| Box quantity | 10 vials |
| Price from | $9.09 per vial ($90.85 per box) |
| Research status | Approved in the US as bremelanotide for one specific indication. Not approved in the UK. Research-grade material is not the approved pharmaceutical product. |
| Documentation | Batch-specific COA (Janoshik or Freedom Diagnostic) |
Nominal specifications. The authoritative figures for any given box are those printed on its batch COA.
Pricing
How much does PT-141 cost?
PT-141 starts at $9.09 per vial (£7.18), sold in boxes of 10 at $90.85. One box is the smallest order and there is no trade account or minimum spend. Larger volumes are negotiable.
| Strength | Per vial | Box of 10 |
|---|---|---|
| 10 mg | $9.09 £7.18 | $90.85 £71.77 |
Handling
How should PT-141 be stored and reconstituted?
Full explanation of why each of these matters: peptide handling and storage reference.
Research Context
What is PT-141 researched for?
Below is a plain-English summary of what published research has investigated, and what it has found. These are descriptions of research activity and published results. They are not claims about what PT-141 does, and nothing here is a statement that it is safe or effective for any purpose.
Central rather than vascular action
Unlike compounds that act on blood flow, PT-141 works through melanocortin receptors in the central nervous system. That difference in mechanism is the reason it was developed and the focus of most of the research. 12
MC3R and MC4R selectivity
Changing the C-terminal amide of Melanotan II to a free acid reduces activity at MC1R, the pigmentation receptor, and shifts the profile toward MC3R and MC4R. It is a textbook demonstration of how one terminal change redirects receptor selectivity.
Melanocortin receptor mapping
Used alongside Melanotan II in binding assays to determine which receptor subtype is responsible for which observed effect, since the two differ at a single position.
References
- 1Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials (RECONNECT). Obstet Gynecol (2019). PMID 31599840
- 2Long-Term Safety and Efficacy of Bremelanotide for Hypoactive Sexual Desire Disorder. Obstet Gynecol (2019). PMID 31599847
Links open the record on PubMed or PubMed Central. These are citations to published research, not claims about this product.
Applications
Where PT-141 is used in the laboratory
- Melanocortin receptor subtype selectivity studies, particularly MC3R and MC4R
- Comparative binding research against Melanotan II
- Cyclic peptide conformational stability studies
- Structure-activity relationship research on alpha-MSH analogues
Verification
Does PT-141 come with a COA?
Yes — every box. Each batch of PT-141 is analysed by Janoshik Analytical or Freedom Diagnostic. The certificate confirms identity by mass spectrometry and purity by HPLC, and is tied to the batch number printed on the vial label. You can ask to see it before you order.
Example COA. You receive the certificate matching your own batch.
Questions
PT-141 questions, answered
How is PT-141 related to Melanotan II?
PT-141 is a metabolite of Melanotan II. The two share an identical cyclic core; PT-141 terminates in a free carboxylic acid where Melanotan II carries an amide. That difference reduces activity at MC1R, the receptor most associated with pigmentation, which is why the two show measurably different selectivity profiles.
How much does PT-141 cost?
PT-141 starts at $9.09 per vial, sold in boxes of 10 vials at $90.85 per box (about £71.77). 1 strength available: 10 mg. There is no minimum order.
What purity is your PT-141?
All batches test at 99%+ purity. Every box ships with a batch-specific Certificate of Analysis from Janoshik Analytical or Freedom Diagnostic, confirming identity by mass spectrometry and purity by HPLC.
Is there a minimum order for PT-141?
No. You can order a single box of 10 vials. There is no trade account, bulk commitment or minimum spend.
How is PT-141 shipped?
Tracked and in discreet, plain packaging, dispatched within 1–3 working days. Delivery estimates are UK 5–7 working days, EU 8–10, USA 5–8 and rest of world 10–12. Full detail is on the shipping page.
Catalog
